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After subcutaneous administration of 14 C-nafarelin acetate to men, 44–55% of the dose was recovered in urine and –% was recovered in feces. Approximately 3% of the administered dose appeared as unchanged nafarelin in urine. The 14 C serum half-life of the metabolites was about hours. Six metabolites of nafarelin have been identified of which the major metabolite is Tyr-D(2)-Nal-Leu-Arg-Pro-Gly-NH 2 (5–10). The activity of the metabolites, the metabolism of nafarelin by nasal mucosa, and the pharmacokinetics of the drug in hepatically- and renally-impaired patients have not been determined.

After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol. [26] In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism . [27] After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .

Life Science > Nutrition Research > Learning Center > Plant Profiler > Maca ( Lepidium meyenii )

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