Aminosteroid neuromuscular blocking drugs

Jehovah's Witnesses and Blood Issues
Jehovah's Witnesses are well known for their refusal of blood transfusions. But how much do you really know? What can or can't they have, are epidural blood patches acceptable and what rights do parents have to refuse their children blood transfusions? This article discusses these issues as well as giving background on who are Jehovah's Witnesses and what they believe in. It also covers the area of consent in both children and adults according to New Zealand law.
Length of Study: 5 0 min
Difficulty:  Medium
   

Excessive doses of PAVULON® (pancuronium bromide injection) produce enhanced pharmacological effects. Residual neuromuscular blockade beyond the time period needed may occur with PAVULON® (pancuronium bromide injection) as with other neuromuscular blockers. This may be manifested by skeletal muscle weakness, decreased respiratory reserve, low tidal volume, or apnea. A peripheral nerve stimulator may be used to assess the degree of residual neuromuscular blockade and help to differentiate residual neuromuscular blockade from other causes of decreased respiratory reserve.

Ten ♀ Balb/c mice weighing approximately 23 g were separated in 3 groups. Group 1 (3 mice) was treated . with RM-133 (240 mg/kg/ mL, twice a day (AM and PM), every other day) in aqueous % methylcellulose:EtOH (92:8). Group 2 (3 mice) was treated . with RM-133 (120 mg/kg/ mL, twice a day (AM and PM), every other day) in sunflower oil:EtOH (92:8). Group 3 (4 mice) received only one injection of RM-133 (120 mg/kg/ mL) in aqueous 25% β-cyclodextrin:EtOH (92:8) and were sacrificed 24 h later. Mice in groups 1 and 2 received a total of 8 injections over 4 days and were sacrificed on day 8. Mice behavior was monitored during the whole duration of the experiment, and macroscopic observation of organs was performed upon necropsy.

Aminosteroid neuromuscular blocking drugs

aminosteroid neuromuscular blocking drugs

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