Cardiovascular effects of PACAP and PACAP(6â38) in the RVLM of normotensive and hypertensive rats. A and B: changes in mean arterial pressure (MAP; i), HR (ii), and percentage of sSNA (iii) before and after the administration of PACAP (A) or PACAP(6â38) (B). Arrows indicate times of drug infusion. âPBSâ indicates the period after the bilateral RVLM microinjection of PBS; âPACAPâ and âPACAP(6â38)â indicate the periods after the bilateral RVLM microinjection of PACAP or PACAP(6â38), respectively. C: comparison of maximum MAP (i), HR (ii), and percentage of sSNA responses (iii) after PACAP or PACAP(6â38). *P < ; **P < ; ***P < .
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