Distribution : Following intravenous administration of 1 mg of fluticasone propionate in healthy volunteers, the initial disposition phase for fluticasone propionate was rapid and consistent with its high lipid solubility and tissue binding. The apparent volume of distribution averaged L/kg (range, - L/kg). The percentage of fluticasone propionate bound to human plasma proteins averaged 91%. Fluticasone propionate is weakly and reversibly bound to erythrocytes. Fluticasone propionate is not significantly bound to human transcortin.
Antibiotics – Neosporin and Polysporin are popular topical antibiotics that come in both a cream and ointment form. Neosporin consists of three different antibiotics, neomycin sulfate, polymixin B sulfate and bacitracin. Polysporin is a combination of two antibiotics, bacitracin and polymixin B sulfate. Generic versions of topical antibiotics are also available, usually marketed as “triple antibiotic” ointment or cream. Topical antibiotics are used to aid healing of minor cuts, scrapes, and burns. Since many people are allergic to neomycin, it may be best to use a topical antibiotic that does not contain this ingredient.