In addition to adverse reactions reported from clinical trials, the following adverse reactions have been identified during postapproval use of albuterol sulfate. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, or causal connection to albuterol or a combination of these factors.
Symptoms: signs and symptoms of salbutamol overdose are transient phenomena, pharmacologically mediated by beta-adrenoreceptors stimulation, such as low arterial blood pressure, tachycardia, muscle tremors, nausea, vomiting. Application of large salbutamol doses can cause metabolic changes, including hypokalemia, it is necessary to control potassium concentration in blood serum. At high doses, as well as at overdose with short-acting beta-agonists lactic acidosis was observed, so in case of overdose control over rise of serum lactate and possibility of metabolic acidosis can be indicated (especially at maintaining tachypnea or its exacerbations, despite eliminating other signs of bronchoconstriction, such as wheezing).