In the Peyronie's disease clinical studies, at 6 weeks after the first treatment cycle of XIAFLEX mg, approximately 75% of patients had antibodies against AUX-I and approximately 55% of patients had antibodies against AUX-II. Six weeks after the eighth injection (fourth treatment cycle) of XIAFLEX, >99% of XIAFLEX-treated patients developed high titers of antibodies to both AUX-I and AUX-II. Neutralizing antibodies were assayed for a subset of 70 samples selected to be representative of high and low titer binding antibody responses at week 12 of treatment. For each subject in whom a Week 12 sample was selected, the corresponding Week 6, 18, 24, and 52 samples were assayed if they were also binding antibody positive. Neutralizing antibodies to AUX-I or AUX-II, were detected in 60% and %, respectively, of patients tested.
I dont know if I have trigger finger or Dupuytren’s Contracture and getting the VA to do test is dam near impossible. My fingers are straight and can bend. However, keeping them straight I have a constant burning sensation in my palm (left). In the past and when I exercise (use to) my hands would look up in what I describe as a claw. I would have to force them to straighten and hold them that way until it passes. My hand never made a popping sound. I feel no pain just burning. I can no longer do push ups and some other exercise due to my hand. Fingers on my right hand can be raised as if I was trying to pop the joint. But on my left hand they are like trying to straighten a steel bar, thus unable to “pop” the joint. Extension that is what I meant by popping.