Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease . 
FDA reviewed a sampling of cases from the FDA Adverse Event Reporting System (FAERS) database, as well as cases in the medical literature of serious neurologic adverse events associated with epidural corticosteroid injections. 2-16 Serious adverse events included death, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, stroke, seizures, nerve injury, and brain edema. Many cases were temporally associated with the corticosteroid injections, with adverse events occurring within minutes to 48 hours after the corticosteroid injections. In some cases, diagnoses of neurologic adverse events were confirmed through magnetic resonance imaging or computed tomography scan. Many patients did not recover from these reported adverse events.
Understanding the mechanisms of action of corticosteroids is critical for knowing when they can be used for treatment and why they are more potent than NSAIDs for painful shoulder conditions. The inflammatory process begins with activation of phospholipase A 2 , which converts phospholipids to arachidonic acid. Mediators of inflammation are then produced from arachidonic acid, which is converted into endoperoxides by cyclooxygenase (COX) or into hydroperoxides by lipoxygenase. Endoperoxides and hydroperoxides are further converted into other inflammatory mediators.