Katarak karena steroid

The researchers’ analysis of registry data for 837,795 live-born infants in Denmark between 1996 and 2008 found no link between the use during pregnancy of the anti-herpetic agents acyclovir, famciclovir or valacyclovir and the occurrence of major birth defects, after adjusting for several variables. Of 1,804 pregnancies exposed to one of these antivirals at any time during the first trimester, 40 infants ( percent) had a diagnosis of major birth defect, as compared with 19,920 of 835,991 ( percent) unexposed pregnancies. [JAMA 2010;304(8):859-866]

Research also shows that there are several risk factors which we can control simply by changing our behavior. These preventive actions include: quitting smoking, wearing UVA/UVB protective eyewear and wide brimmed hats to reduce UV exposure, trying to reduce the risk other diseases such as diabetes, and eating a healthy, well-balanced diet. Several studies have shown that the antioxidant properties of vitamins C and E may also help to protect against the development and progression of cataracts. Most fruits and vegetables are excellent sources of vitamin C, including oranges, grapefruit, strawberries and papaya, as well as green peppers and tomatoes.

Age: It is very common in people over 65 years of age.

Despite studies, it is unknown exactly why cataracts form as the lens ages. While the factors are being gradually identified, some doctors believe that diet with high antioxidants (beta-carotene, vitamins A, C and E, and selenium) may help keep cataracts at bay. However none of these theories has been conclusively proven.

Ultraviolet light – eye doctors advise the use of sunglasses and wide-brim hats to protect against UV light exposure which is suspected to be associated with cataract development.

X-ray exposure – according to a 2005 Iceland study, airline pilots and astronauts are at higher risk of developing nuclear cataract due to cosmic radiation exposure.

Steroids, diuretics and major tranquilisers - some of these are suspected to cause cataract but further proof is yet to be established. Steroid use in particular is associated with cataract development.

Other risk factors – too much salt, alcohol, air pollution and smoking are also associated with cataract formation. Again all these processes are difficult to prove. There is evidence to show that diabetics are more prone to cataract formation.

Purpose. To review the role of steroids in the management of uveitic macular edema. Methods. Review of recent literature on the physiopathology of macular edema and clinical trials involving steroids as main treatment of uveitic macular edema. Results. The steroid-glucocorticoid receptor complex regulates the action of specific steroids allowing transactivation or repression of a common as well as a unique set of genes. This specificity may help explain differences observed in the side effect profile of commonly used intraocular steroids (dexamethasone, fluocinolone, triamcinolone) whose ability to activate glucocorticoid receptors in model systems is very similar. Sustained delivery devices provide long-term remission of macular edema but with an increased incidence of cataract and glaucoma procedures. The exact incidence is dependent on the specific steroid, the mode of delivery, and the time since injection/placement. Steroid therapy is able to target many important pathways in uveitic macular edema, achieving good clinical results. Secondary adverse effects are still a matter of concern limiting their use. Conclusions. Steroid therapy remains a mainstay in the management of uveitic macular edema. Local administration precludes systemic adverse effects even though the risk of developing cataract or glaucoma remains an important issue. New slow release devices are thought to improve safety profile while keeping therapeutic advantages.

Katarak karena steroid

katarak karena steroid

Purpose. To review the role of steroids in the management of uveitic macular edema. Methods. Review of recent literature on the physiopathology of macular edema and clinical trials involving steroids as main treatment of uveitic macular edema. Results. The steroid-glucocorticoid receptor complex regulates the action of specific steroids allowing transactivation or repression of a common as well as a unique set of genes. This specificity may help explain differences observed in the side effect profile of commonly used intraocular steroids (dexamethasone, fluocinolone, triamcinolone) whose ability to activate glucocorticoid receptors in model systems is very similar. Sustained delivery devices provide long-term remission of macular edema but with an increased incidence of cataract and glaucoma procedures. The exact incidence is dependent on the specific steroid, the mode of delivery, and the time since injection/placement. Steroid therapy is able to target many important pathways in uveitic macular edema, achieving good clinical results. Secondary adverse effects are still a matter of concern limiting their use. Conclusions. Steroid therapy remains a mainstay in the management of uveitic macular edema. Local administration precludes systemic adverse effects even though the risk of developing cataract or glaucoma remains an important issue. New slow release devices are thought to improve safety profile while keeping therapeutic advantages.

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