Diaper dermatitis (napkin rash) is a skin disease which can be seen in diaper areas of babies as rubor and in more serious cases as bulla and open wounds. For treatment in necessary conditions, it is suggested to use Antifungals and/or -1% hydrocortisone pomads in addition to symptomatic therapy such as moistening of the skin and removal of irritant agents from area. Seven-months-girl and six-months-boy case was brought with excess weight intake complaints. They were excessivly obese and had an increase adipose tissue under their skins. Both cases had used pomads involving clobetasol 17-propionate for the last 3 months. Their family history was normal. Serum ACTH levels was
Education Dr. Gedikolu had his high school education in Isik Lisesi (Istanbul) and thereafter, he entered the Istanbul Faculty of Medicine in Istanbul University. After obtaining the medical doctor degree, he did his military service in the Field Officer School of the Sixth Army in Smyrna; and he had the first position while finishing the military service. He was accepted to the Baylor University in Houston to perform a residency in pediatrics. He did his subspecialty in Pediatric Hematology and Oncology in St. Paul Hospital and in the Wadley Research Center. Studies in Genetics He was accepted into the Cardiff University to perform research in genetics with the grand of the British Council. He transferred his experience in Cardiff to perform research in Istanbul Faculty of Medicine. Heterochromasy in Human Chromosomes Until 1966, existence of the heterochromatic regions in the chromosomes was well known in plants and animals, yet there was no information regarding to their presence in human chromosomes. First in 1966, Dr. Gedikolu observed such regions in chromosomes of a 22-years old Caucasian male bearing Wilson disease independent of the disease and published these observations in Lancet. New Observations in Kartagener's Disease In 1933, Kartagener described a new syndrome comprised of a symptoms trio of dextrocardia, bronchiectasis and sinusitis; and therefore, this syndrome is named as Kartagener's triad or syndrome. New research confirmed that this disease phenotype may associate with multiple chromosomal regions. Most frequently, the dynein axonemal intermediate chain protein locus (9p21-p13) exerts mutations; yet 5p and 19q anomalies are also linked with the similar disease phenotypes. In 1967, Dr. Gedikolu described new findings in a sibling born from nephew-parents with Kartagener symptoms. While documenting the existence of fibrocystic lung disease in both patients, and the eosinophilic infiltration in the sinonasal epithelium as a novel finding; he also described isolated green color blindness (deuteranopia) in one of the siblings and published these clinical data again in Lancet (3). Isolated color blindness could be the first sign of degenerative eye diseases with progressive rode-cone injury (64) and one gene causing one of such diseases, the retinitis pigmentosa is localized also in 19q similar to the gene of Kartagener's (65, 66). Only very recently, it is found that the motile flagellum and the immotile sensory cilia can bear the same structural proteins (67); and in 2001 Kartagener's syndrome-accompanying retinitis pigmentosa is described (68).
Tarihçe Jüvenil idyopatik artrit, birtak>m eski hastal>klar>n yeni ortak ad>d>r. Jüvenil idyopatik artrit, jüvenil romatoid artrit (JRA) ve jüvenil kronik artrit (JKA) yerine geçen ve her iki eski tan>m> da ortak olarak kapsayan bir terimdir. Jüvenil idyopatik artrit, yüzy>llar öncesinden beri tan>nan bir hastal>kt>r. Yap>lan arkeolojik çal>flmalarda . 1000 y>llar>ndan kalma iskelet de¤iflikliklerinin oldu¤u kronik artritli çocuk kal>nt>lar> bulunmufltur. Hastal>¤>n 1500'lerde tan>mlanmas>na karfl>n özenli çal>flmalar 1800'lerde Cronil ve Diamestberg'in çal>flmalar>na kadar yap>lmam>flt>r. 1890 y>l>nda kronik artritli çocuklarda büyüme bozukluklar> iki araflt>rmac> taraf>ndan ilk kez bildirilmifltir. Bunu izleyerek 1897'de Dr. George F. Still taraf>ndan yap>lan titiz çal>flma ile çocuklardaki süregen artritin yetiflkinlerdeki romatoid artritten oldukça farkl> oldu¤u gösterilmifltir. 1972 y>l>nda Amerikan Romatoloji Birli¤i (ACR), JRA olarak adland>r>lan hastal>¤> klinik formlar>na göre sistemik bafllang>çl>, oligoartiküler ve poliartiküler tip olmak üzere 3 alt tipe ay>rm>fllard>r. Fakat bu s>n>flaman>n hastal>¤>n baz> tiplerini tam olarak aç>klayamad>¤>n> düflünen Avrupa romatizma ile savafl ligi (EULAR)'a ba¤l> pediatrik romatoloji grubu, 1977 y>l>nda hastal>¤> jüvenil kronik artrit (JKA) olarak adland>r>p yeniden s>n>fland>rd>. Bu s>n>flamaya göre hastal>k klinik formlar>na göre oligoartiküler, RF pozitif poliartiküler, RF negatif poliartiküler, jüvenil spondilartropati, jüvenil ankilozan spondilit, jüvenil psoriatik artrit ve yang>sal barsak hastal>klar> ile iliflkili artrit olarak alt tiplere ayr>lm>flt>r (1-16). Uluslararas> bir s>n>fland>rma oluflturmak amac>yla 1995 y>l>nda Santiago'da toplanan Avrupal> ve Amerikal> bilim adamlar> hastal>¤> Jüvenil <dyopatik Artrit (J<A) olarak adland>r>p uluslararas> romatizma ile savafl ligi (ILAR) s>n>flamas>n> oluflturdular (17,18,19). (Tablo I)