All existing trials of colchicine in pericarditis have been conducted by similar research groups. The data were extracted using an agreed data extraction form. Colchicine: its mechanism of action and efficacy in crystal-induced inflammation. Although we do not have definitive evidence that colchicine increases the risk of adverse events overall, it was associated with higher therapy withdrawal rates than the control group. Takav su na primer alopurinol i probenecid. Selection criteria RCTs of people with acute or recurrent pericarditis who are receiving colchicine compared to any other treatment, in order to prevent recurrences.