Pharmacology steroid therapy

"Axis Recovery"

  • Slow reduction in dose over extended period of time
  • change dose rate every 3-4 weeks, change to EOD for first reduction
  • No ACTH (maintains negative feedback on hypothalamus)
  • Remember extra pred. for "stress"
  • Daily replacement therapy
    • Prednisone or prednisolone preferred
    • 1 mg/kg of hydrocortisone activity each day (dog)
    • - mg/kg prednisone, prednisolone "normal" secretion rate not known for other species
  • "Stressful" Situations
    • additional prednisone or prednisolone
Anti-inflammatory and Anti-immunologic Therapy Steroids are potent drugs for interrupting events triggered at the cell membrane (prostaglandins, phospholipase, etc.), and cell mediated immunity (antigen recognition, cell migration, etc.)

Athletes and bodybuilders have recognized for several decades that the use of anabolic steroids can promote muscle growth and strength but it is only relatively recently that these agents are being revisited for clinical purposes. Anabolic steroids are being considered for the treatment of cachexia associated with chronic disease states, and to address loss of muscle mass in the elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life. In sport, these agents are performance enhancers, this being particularly apparent in women, although there is a high risk of virilization despite the favourable myotrophic–androgenic dissociation that many xenobiotic steroids confer. Modulation of androgen receptor expression appears to be key to partial dissociation, with consideration of both intracellular steroid metabolism and the topology of the bound androgen receptor interacting with co-activators. An anticatabolic effect, by interfering with glucocorticoid receptor expression, remains an attractive hypothesis. Behavioural changes by non-genomic and genomic pathways probably help motivate training. Anabolic steroids continue to be the most common adverse finding in sport and, although apparently rare, designer steroids have been synthesized in an attempt to circumvent the dope test. Doping with anabolic steroids can result in damage to health, as recorded meticulously in the former German Democratic Republic. Even so, it is important not to exaggerate the medical risks associated with their administration for sporting or bodybuilding purposes but to emphasize to users that an attitude of personal invulnerability to their adverse effects is certainly misguided.

Pharmacology steroid therapy

pharmacology steroid therapy


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