The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . 
In addition to the mentioned side effects several others have been reported. In both males and females acne are frequently reported, as well as hypertrophy of sebaceous glands, increased tallow excretion, hair loss, and alopecia. There is some evidence that anabolic steroid abuse may affect the immune system, leading to a decreased effectiveness of the defense system. Steroid use decreases the glucose tolerance, while there is an increase in insulin resistance. These changes mimic Type II diabetes. These changes seem to be reversible after abstention from the drugs.
While it may sound overly simplistic, one of the best things you can do to combat Dianabol side-effects is to live a healthy lifestyle. This shouldn’t come as a surprise, after all, to maintain a proper blood pressure and healthy cholesterol levels you must live a healthy lifestyle. For this reason, you are encouraged to keep an eye on your diet; stay away from foods that are junky, and be sure to get in plenty of healthy fats, as such foods will greatly serve you in a tremendous fashion. Foods that contain omega-3 fatty acids will serve you well. Further, abstaining from alcohol is a great idea, as is any other activity that might bring about undue stress to the body. If you can do these things, keep your doses moderate and supplement for proper periods of time, almost all of you will be fine. We say almost all for one simple reason, we are all unique individuals, and there may be some who even when responsible have problems. Look at it this way, some of us can drink milk, while others can’t and such is the nature of life. Even so, through responsible use, Dianabol side-effects as you can see are very easy to control.