In a performance setting, Cytomel doses will be very similar to hypothyroidism treatment plans. The individual will normally begin with 25mcg per day and increase the total dose -25mcg every 2-4 weeks as needed. Most will find they will have no need to go above 75-100mcg per day, with the 125mcg per day range being acceptable for very short periods of time. Such a high dose might be acceptable at the end of a harsh contest diet but should not be a regular dose through the brunt of the diet. As for total use, 6-8 weeks will be the safest total duration. Longer can be acceptable, such as 8-12 weeks, but it does increase the risk of thyroid dependency. However, most healthy adults should not have an issue. Once you have reached your high end dose and it’s time to come off, you are encouraged to drop the dose down to 25mcg per day and hold at that dose for 7-10 days. This will allow the body to adjust and protect you from falling into hypothyroidism. For no reason should you discontinue use abruptly, the 7-10 day low dose is imperative.
Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.
Anabolic steroids can cause the development of acne. However, the extent to which it is experienced can be due to a number of varying factors, with the particular steroids and exact dosages used being primary. The skin´s sebaceous glands have a particularly high affinity to Dihydrotestosterone, which is an androgen the body naturally produces from testosterone via the enzyme 5-alpha Reductase. Increased sebaceous gland activity promotes oily skin which can combine with bacteria and dead skin (normal wear and tear) eventually causing pores to become clogged more quickly than the body can cleanse them. This of course, is preventable by using only particular steroids, cleansing the skin regularly, and perhaps using a topical anti-androgen.